San Diego Cruises
San Diego Cruises
Sail from the port of San Diego in sunny California
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Cruise lines sailing from San Diego, CA

Cruise lines sailing from San Diego
Get ready to kick off your sun-filled escape on cruises departing from San Diego! Take your pick of top-tier cruise lines featuring globally acclaimed dining, live entertainment, bustling venues, and thrilling activities that are bound to amaze as you cruise toward your next epic adventure.

Destinations from San Diego, CA

Destinations from San Diego
Cruise from San Diego with sailings to the world’s most sought-after destinations like Mexico, Hawaii, Central America, and beyond. Head to the golden beaches of Mexico, where you can relax with refreshing margaritas and enjoy authentic Mexican street food all day long. In Hawaii, plunge into exciting snorkeling adventures, encounter mesmerizing wildlife, and immerse yourself in captivating local entertainment, creating an unforgettable mix of relaxation and adventure.
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Cruises from San Diego

Cruise from San Diego today! Set sail for relaxing beaches aboard world-class cruises from Disney Cruise Line, Holland America Line, Norwegian Cruise Line, and more. Whether you crave adventure in Hawaii or a peaceful escape in Mexico, book with Cruises.com to get all the deals the cruise lines offer, plus exclusive deals you’ll only find with us. Our Cruise Experts are available to help you book your dream cruise from San Diego 24/7.